ORGN 585 |
| The attachment of common fluorophores such pyrene, perylene and benzopyrene to the deoxyribose scaffold of DNA has been shown to render configurationally-stable ‘fluorosides'. Libraries of DNA-like polymeric fluorosides, or ‘polyfluors', can be synthesized by employing split and pool combinatorial chemistry techniques. These polyfluors have been previously reported to exhibit a broad range of emission colors with a single wavelength excitation. Stacking effects interplay with charge and energy transfer mechanisms to allow a range of colors, intensities, and sensing responses. In this study, libraries of polyfluors were synthesized as conjugates to DNA oligonucleotides. These were screened for fluorescence responses upon addition of complementary DNAs. Results have shown a variety of fluorescence responses to hybridization, allowing for rapid identification of soluble sensors of DNA sequences.
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New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
