INOR 135 |
| Cisplatin derivatives containing replaceable oxygen donor ligands are of considerable interest, as carboplatin and satraplatin have displayed reduced resistance and better antitumor activity relative to cisplatin. Here we report the synthesis of a series of platinum(II)- and platinum(IV)-pyrophosphato complexes and their characterizations by 31P and 195Pt NMR and X-ray crystallography. These complexes include diamminepyrophosphato platinum(II), cis-diammine-trans-dihydroxopyrophosphato platinum(IV), (trans-diaminocyclohexyl)-pyrophosphato platinum(II), (trans-diaminocyclohexyl)-trans-dihydroxopyrophosphato platinum (IV), and ethylenediamminepyrophosphato platinum(II). The kinetics of oxidation of several platinum(II)-pyrophosphato complexes by hydrogen peroxide followed a second order process, independent of pH in the range 7 to 9, with rate constants lying in the range of 2.3E-2 to 4.9E-2 s-1M-1. Preliminary data indicate excellent anticancer activity towards ovarian cell lines perhaps due to improved transport across the cell membrane through the phosphate ion channels. |
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Bioinorganic Chemistry
7:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Inorganic Chemistry |