INOR 114 |
| High aspect ratio nanoparticles, or nanowires, have been fabricated and their interaction with mammalian cells has been quantified by optical microscopy. The deposition of nickel or ferric oxide segments enables magnetic manipulation of the nanowires with an applied field. Single- and multi-segment magnetic nanowires provide an excellent platform for cell manipulations because their large magnetic moments allow for the application of large forces to cells. Cell separations employing nanowires show increased effectiveness compared to magnetic beads. Organic molecules with appropriate ligands selectively bind to discrete segments of multi-segment metal and metal oxide nanowires. Techniques utilizing this selective surface chemistry enabled binding of a cell specific antibody. For example, nickel nanowires have been functionalized with mouse anti-human E-cadherin antibody, which shows selectivity toward epithelial cells. Magnetic separation revealed an enhancement in the population of this cell type from a heterotypic culture. |
|
Nanoscience: Applications
1:30 PM-4:30 PM, Sunday, 10 September 2006 Moscone Center -- Room 309, Oral
Division of Inorganic Chemistry |