Morinda citrifolia L. Noni: An angiotensin converting enzyme inhibitor

AGFD 130

Afa K. Palu, afap@tni.com1, Bing-Nan Zhou, bing_nan_zhou@tni.com2, Shixin Deng, shixin-deng@tni.com1, and Brett J. West, brettw@tni.com3. (1) Noni Benefits Research, Tahitian Noni International Research Center, 737 East 1180 South, American Fork, UT 84003, (2) Research and Development Department, Tahitian Noni International, 737 East 1180 South, American Fork, UT 84003, (3) Research and Development, Morinda Inc, 737 East 1180 South, American Fork, UT 84003
Morinda citrifolia L. Noni has been used in Polynesia for over 2000 years and is reputed to have an array of health benefits. Taditional healers have been using different parts of the Noni tree to treat pain, inflammation, diabetes, gout, cancer, high blood pressure and many more that have been listed by others. The number of people purported to have lowered their high blood pressure from drinking TAHITIAN NONI (R)Juice (TNJ)is increasing. Our focus is to elucidate the possible mechanisms by which Noni and TNJ lowers high blood pressure. Noni fruit juice concentrates (NFJC) and TNJ were used in different concentrations [1%, 5%, 10%]on ACE enzyme and Angiotensin AT receptors bioassays. TNJ in 1% and 5% inhibited ACE enzymes by 105% and 113% respectively in a dose dependantly fashion. TNJ also binds to and inhibited the AT1 receptors with an IC50 1.6% and AT2 receptors with an IC50 4.13%. However, NFJC bind to and inhibited AT1 receptors with an IC50 1.97% and IC50 2.29% for AT2 receptors respectively. The preliminary data seems to suggest that Noni and TNJ possible effects on lowering high blood pressure is through inhibitory effects on angiotensin converting enzymes and act antagonistically on the angiotensin receptors. A human clinical trial should be considered in light of this data to confirm these effects in-vivo.