Cation transport by redox-active synthetic ion channels

PHYS 466

Cristina Suárez, csuarez@smith.edu1, Adam C. Hall, ahall@smith.edu2, C. Dennis Hall, cdhall@chem.ufl.edu3, Anu Maharjan, amaharja@email.smith.edu4, and Angela Saquibal, asaquiba@smith.edu4. (1) Department of Chemistry, Smith College, Northampton, MA 01063, (2) Department of Biological Sciences, Smith College, Northampton, MA 01063, (3) Department of Chemistry, University of Florida, Gainsville, FL 32611, (4) Biochemistry Program, Smith College, Northampton, MA 01063
The synthesis and transmembrane conductive properties of a novel group of synthetic ion channels are described. The potential ion channel group of macrocycles, and cryptands containing metallocenes and electroactive units is in the process of being synthesized and characterized. Experiments using a black lipid membrane preparation reveal that these compounds can function effectively as ion channels. Subsequent 23Na NMR spectroscopy studies have focused on the characterization of ionic flux. When incorporated into a vesicular bilayer, our first ferrocene synthetic ion channel demonstrated to support a Na+ flux that was at least six times faster than ion transport by monensin, a known ion transporter. Further 23Na NMR spectroscopy studies are being conducted on newly synthesized channels.

Poster Session
7:30 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster

8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Physical Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006