Enantiomerically pure abscisic acid conjugates for use in chemical genomics

BIOL 114

Timothy R. Smith, msraac@warwick.ac.uk1, Andrew Marsh, a.marsh@warwick.ac.uk1, and Andrew J. Thompson, a.j.thompson@warwick.ac.uk2. (1) Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom, (2) Warwick HRI, Wellesbourne, Warwick CV35 9EF, United Kingdom
Abscisic acid is an important phytohormone implicated in many growth and regulatory processes in plants. Dissecting this signalling network with 'biopanning' procedures requires access to biologically active, enantiomerically pure abscisic acid conjugates suitable for immobilisation. We present a new, short synthesis that allows the preparation of either enantiomer of abscisic acid in 30% overall yield. Phage display and affinity-based methods are being used with enantiomerically pure analogues to identify target proteins.

 

Chemistry and Metabolism
4:30 PM-6:30 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Division of Biological Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006