ANYL 216 |
| Ion-selective membrane electrodes form a class of well established sensors that have found important applications, especially in clinical analysis. This talk will show how the detection limit of such sensors has been reduced to ultra-trace levels by understanding and optimizing key parameters that are responsible for the measurement bias at low sample concentrations. Today, a palette of such sensors for trace analysis is available, and efforts continue towards making this technology available to non-specialists in the field by fabricating robust systems. In addition, zero current potentiometry is, ideally, a non-perturbing technique that allows one to miniaturize the sensor and the sample without altering the observables in any way. Consequently, trace level potentiometry in confined samples has the promise of becoming one of the most sensitive electranalytical techniques available. Efforts in this direction will be described, as well as the use of such sensors to detect DNA hybridization and immunological binding events with high sensitivity using metal nanoparticle labels. |
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Honoring Joe Wang, Recipient of the Electrochemical Analysis Award
8:30 AM-12:00 PM, Tuesday, 12 September 2006 Moscone Center -- Room 123, Oral
Division of Analytical Chemistry |