Ion mobility-mass spectrometry (IM-MS) as a structural probe of gas-phase ions

PETR 156

David H. Russell, russell@mail.chem.tamu.edu, Department of Chemistry, Texas A&M University, 3255 TAMU, College Station, TX 77843
Laser desorption ionization (LDI) coupled with ion mobility-mass spectrometry (IM-MS) provides rapid (µs-ms)two-dimensional separation of complex mixtures. Over the past several years we have successfully applied this technology to structure analysis of complex biological samples, peptides, oligonucleotides, glycoconjugates, and lipids), and more recently we have demonstrated the utility of the technique for characterization of small molecules and complex mixtures of high molecular weight hydrocarbons. The fundamentals of IM-MS will presented and the utility of technique will be demonstrated by the analysis of small molecules and high molecular hydrocarbons.