Highly sensitive and specific nucleic acid sensor based on photon upconverting particles

ANYL 116

Peng Zhang, pzhang@nmt.edu1, Snezna Rogelj2, Khoi Nguyen1, and Damon Wheeler1. (1) Department of Chemistry & Laboratory of Nanomaterials Science, New Mexico Tech, Socorro, NM 87801, (2) Department of Biology, New Mexico Tech, Socorro, NM 87801
We have designed and developed a novel sensor that reports the presence of specific nucleic acids in solutions, based on photon upconverting particles. The significantly high signal-to-noise ratio of photon upconverting particles leads to high sensitivity of the sensor. The sensor does not suffer from photobleaching. It also displays high specificity and self-calibrating capability. We expect nucleotide sensors of this type to be effective for applications in both DNA/RNA detection and protein-DNA/RNA interaction studies.
 

General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Analytical Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006