ANYL 96 |
| It is well known that vitamin D3 1, a triene-containing active pharmaceutical ingredient undergoes cis-trans isomerization when exposed to light at wavelengths < 330 nm. However, it was observed that this isomerization also occurs in formulations exposed to light of wavelengths well outside the absorption spectrum of 1 (330-436 nm). The cause of this unexpected photoinstability of the triene was explored as a function of wavelength under accelerated light exposure. The results suggest that photoisomerization of 1 is mediated by gelatin which is a fundamental component of many pharmaceutical formulations. Luminescence spectroscopy was used to further understand the role the gelatin serves in mediating the photo-isomerization.
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General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Analytical Chemistry |
