BIOL 134 |
| Peptide nucleic acid (PNA) is a synthetic DNA analogue with uncharged pseudo peptide backbone, which has high potential to be the candidates of sequence-specifically recognition reagents. PNAs with modified backbone have been synthesized and shown valuable properties. The Alanine derived PNAs have been prepared and have shown the ability to invade double stranded DNA with high specificity and efficiency. The Arginine derived PNAs have been readily taken-up by human somatic cells as well as embryonic stem (ES) cells, and is less toxic to the cells than the conventional design. We thus conclude that the modified PNAs have the promising potential to be the anti-gene reagents as well as for genetic diagnostic applications. |
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Chemistry and Metabolism
4:30 PM-6:30 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Division of Biological Chemistry |