BIOL 104 |
| In recent years chemical genetics has emerged as a powerful tool for unraveling the function of genes, the proteins they encode and, pivotal to the action of proteins, the cell signaling events they mediate. Therefore the practice of screening compounds for their bioactive potential in 2D cell cultures (the norm) may not be ideal. Aware that chemical genetics is in its infancy, but given its potential in chemical biology is immense we have initiated a study that aims to investigate possible cellular effects (normal and abnormal) of using cells from 2D and 3D environments in screening compounds for their ability to perturb function. It is known that a cells microenvironment affects its normal or abnormal activity. Our research requires us to fuse 3D cell-culture techniques and chemical genetics together, and incorporate as the ‘lynch pin' cell microscopy as our primary visual investigative tool. Our presentation will report our preliminary results. |
|
Chemistry and Metabolism
4:30 PM-6:30 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Division of Biological Chemistry |