BIOL 97 |
| Naturally occurring or synthetic polysaccharides having similar biological activities to those of heparin are referred to as heparinoids. The polysaccharides of seaweed cell wall mucilage are known to be a good source of naturally occurring heparinoids, and have anticoagulant activity. So far, there are fewer reports of anticoagulants from green algae than from brown and red algae. Monostroma latissium is consumed by local inhabitants as a marine vegetable and has been utilizing for medical purpose for centuries in China. The decoction of algae was traditionally used to treat hyperlipidemia, sunstroke and urinary diseases, etc. In the paper, sulfated polysaccharides from Monostroma latissium were isolated and prepared by extraction in hot water, precipitation with ethanol. The chemical characterizations of the sulfated polysaccharides were defined. The anticoagulant properties of the sulfated polysaccharides were compared with those of heparin by studying the activated partial thromboplastin time and prothrombin time using normal human plasma. |
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Chemistry and Metabolism
4:30 PM-6:30 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Division of Biological Chemistry |