CARB 60 |
| Sialic acids are a family of about 50 naturally occurring 2-keto-3-deoxy-nononic acids involved in a wide range of biological processes. Sialic acid-containing glycoconjugates are implicated in a large number of biological phenomena such as cell-cell adhesion, cell growth regulation, immune response, and oncogenesis. As a part of a program to develop new strategies for the synthesis of alpha-sialosides, we propose the synthesis of an oxazolidinone protected thioglycoside sialosyl donor and the study of its influence on the yield and stereoselectivity in glycosylation reactions. For the synthesis of alpha-(2-8)dimers, a sialosyl acceptor bearing an oxazolidinone fused-ring was also synthesized and its reactivity compared to common acceptors.
|
|
General Posters
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Carbohydrate Chemistry |