Divergent synthesis of sulfated N-acetylglucosamine terminated dendrimers

CARB 68

Michelle Lee Creech and Katherine McReynolds. California State University, Sacramento, Sacramento, CA 95650
Dendrimers are a unique class of polymers, distinguished by their three-dimensional globular shape and extensive branching. At the terminal end of these branches, a variety of functional groups may be placed, which provides them with a multitude of physical properties that makes them ideal for studying multivalency. The aim of this study is to synthesize a sulfated N-acetylglucosamine terminated dendrimer. This is done by first sulfating a N-acetylglucosamine terminated ethereal linker that was previously synthesized via reductive animation. Next, the sulfated ethereal sugar-linker is condensed onto an ethereal tricarboxylic acid made via a Michael addition reaction.
 

General Posters
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Division of Carbohydrate Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006