POLY 415 |
| Poly(ethylene glycol) hydrogel networks were crosslinked by tetra-functionalized azides with di-functionalized acetylenes through the highly efficient, copper catalyzed Click chemistry. The pore structure was characterized with cryo-SEM and was compared with hydrogels formed through UV-irradiation crosslinking, of similar molecular weight between crosslinks. It was found that the internal structure of the Click hydrogels was more uniform than the UV-irradiated analog, with a narrow pore size distribution between 5-20 microns, as compared a pore distribution from less than 1 micron to 20 micron pores for the UV-irradiated hydrogels. Hydrogels were also formed at lower copper concentrations to prepare hydrogels for biological systems, since high copper concentrations can affect cell viability. |
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7th International Biorelated Polymers Symposium
6:00 PM-8:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Polymer Chemistry |