MEDI 338 |
| Recent research in our laboratory has centered on the development of polyacrylate and polyacrylamide nanoparticles prepared in water emulsions. Our goal is to use these nanoparticle emulsions for treatment of life-threatening bacterial infections such as those caused by methicillin-resistant Staphylococcus aureus and Bacillus anthracis. One of the problems we have encountered with these polymeric antibiotics is that the surfactant used for the polymerizations can leach away from the nanoparticle in high enough concentrations to cause cytotoxic effects in human fibroblast cells. To circumvent this, we are investigating the development of new types of nanoparticles in which the surfactant molecule is covalently attached to the backbone of the polymer. The synthesis and characterization of these “surfactant-free” nanoparticle systems, and their application to drug delivery, will be discussed. |
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General Poster Session
7:00 PM-9:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Medicinal Chemistry |