Design and synthesis of a folate receptor-targeted chemotherapeutics: Folic acid conjugate of desacetylvinblastine hydrazide (EC 145)

MEDI 54

Iontcho R. Vlahov1, Hari Krishna R. Santhapuram, hkrishna@endocyte.com1, Paul J. Kleindl1, Stephen J. Howard1, Katheryn M. Stanford1, and Christopher P. Leamon, chrisleamon@endocyte.com2. (1) Department of Discovery Chemistry, Endocyte Inc, 3000 Kent Ave., A1-100, West Lafayette, IN 47906, IN, (2) Department of Discovery Biology, Endocyte Inc, 3000 Kent Ave., A1-100, West Lafayette, IN 47906, IN 47906
An efficient synthesis of the folate receptor (FR) targeting conjugate EC145 is described.

 

General Poster Session
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Medicinal Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006