CARB 65 |
| The synthesis of carbohydrates is highly intricate and cumbersome process especially when it comes to selectively protect and de-protect at specified hydroxyl groups. Such mono- and disaccharides are required to prepare various advance intermediates for potential medicinal agents as well as synthones for high value carbohydrate based drugs and drug delivery devices. During classical carbohydrate chemistry solubility of sugar based units results either no reactions or poor transformation into required products. These mono- and disaccharides have shown significant solubility in ionic liquids. Therefore, as a part of developing newer biocatalytic methods for selectivily protecting both primary and secondary hydroxyl groups, we have demonstrated the selectivity using Lipases (Novozyme 435) and Proteases. The mono- and disaccharides studied includes glucose, fructose, mannose, sucrose. The ionic liquids used to solubilize were 1-butyl-3-methylimidazolium hexafluorophosphate and 1-butyl-3-methylimidazolium trifluoromethane sulfonate. The substrates and products were characterized by 1H, 13C-NMR and mass spectral analysis. Details of enzyme-catalyzed reactions, purification and identifications methods will be presented during the meeting. |
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General Posters
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Division of Carbohydrate Chemistry |