CARB 46 |
| Technologies that could simultaneously detect AND isolate specific pathogens from complex mixtures such as serum or culture media in real time are extremely important in the current fight against bioterrorism agents. Current real time detection and separation methods are woefully inadequate as they are extremely time consuming, require extensive reagent handling and specialized training. Also, the effects of exposure are not apparent immediately following contact to a suspected pathogen. Therefore, developing point-of-care devices that provide accurate information about the extent of exposure to individuals is extremely critical. Continued existence of these needs represents an important problem because technologies that can detect and separate pathogens from complex mixtures have inherent limitations. To meet these unmet needs, we have synthesized and characterized nanocomposites that possess dual capabilities, i.e. a magnetic component and an optical component. These iron core gold shell nanocomposites possess carbohydrate ligands on their surface that can be tailored to bind to specific pathogens. In this poster, we present the synthesis of two thiol bearing carbohydrate ligands and iron core–gold shell nanocomposites. In addition, the synthesis and characterization of gold and silver nanorods is presented. These nanorods possess unique optical properties. The synthesis of the nanoparticles, conjugation chemistry and their capacity to detect and separate variants of E. Coli will be presented. |
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General Posters
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Carbohydrate Chemistry |