Submicron fibrous scaffolds based on designer phospholipids and surfactants

POLY 372

Matthew T. Hunley1, Matthew G. McKee2, Matthew P. Cashion, mcashion@vt.edu2, John M. Layman2, and Timothy E. Long, telong@vt.edu2. (1) Department of Chemistry, Virginia Tech, 124 Davidson Hall, Blacksburg, VA 24061, (2) Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212
Entangled, worm-like micelles of the phospholipid mixture lecithin were successfully electrospun. Similar to polymer solutions, fibers were formed at concentrations above the Ce, with uniform fibers forming as the concentration was further increased. Electrospinning a well-defined phospholipid, POPE, resulted in the formation of uniform, submicron fibers at concentrations above the Ce. Melt electrospinning of POPE was also successful, although fibers were significantly thicker. This second method offers a safer and more efficient processing method by eliminating the need for solvent. Both electrospinning techniques provide a one-step method for producing submicron fibrous scaffolds of low molecular weight amphiphiles and surfactants.