MEDI 206 |
| Caffeic acid phenethyl ester (CAPE) is an active component of honeybee propolis extracts. It has several effects such as anti-inflammatory, anti-oxidize, anti-cancer, anti-bacterial, anti-viral, anti-fungal and immunomodulation. Especially, suppressive effect of NF-kB will be interrupt the part of allergic induction. The purpose of this experimental study was to evaluate the effect of CAPE on active systemic anaphylaxis induced by ovalbumin (OVA) challenge in mice. Mice were sensitized intraperitoneally and challenged intravenously by OVA. Anaphylalactic scores, histopathological analysis, and plasma levels of histamine and total IgE after allergen challenge were determined. After challenges, all sham-treated mice developed anaphylactic signs, increased plasma levels of histamine and total IgE, marked vascular leakage, and histological changes including pulmonary edema and hemorrhage in renal medullae within 20 min. In contrast, decrease of plasma levels of histamine and total IgE were observed in CAPE treated mice. In addition, a significant prevention of hemoconcentration and OVA-induced pathological changes. These results suggest that CAPE shows an anti-allergic effect, which may be due to the protection against IgE-mediated allergy. |
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General Poster Session
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Medicinal Chemistry |