POLY 330 |
| A drug for the treatment of Parkinson's disease, L-Dopa, was converted into well-defined dendritic macromolecules which were characterized by MALDI and polyacrylamide gel electrophoresis. A third generation L-Dopa dendrimer contained thirty L-Dopa residues which made up the core, branches and periphery. These Dopa dendrimers showed a twenty-fold increase in aqueous solubility over L-Dopa. In addition, while L-Dopa solutions became colored within a day, the L-Dopa dendrimer solutions remained colorless for several months under identical conditions. Individual L-Dopa moieties in the dendrimers were connected to one another with hydrolyzable diester linkages. This novel concept of transforming a drug into its dendritic form not only yields potential slow release prodrugs but may also demonstrate beneficial properties for drug formulations. |
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7th International Biorelated Polymers Symposium
8:30 AM-12:10 PM, Tuesday, 12 September 2006 San Francisco Marriott -- Salon 14/15, Oral
Division of Polymer Chemistry |