Biosensors: Principles and contemporary issues


Anthony Guiseppi-Elie,, Center for Bioelectronics, Biosensors and Biochips (C3B), Clemson University ChBE, 132 Earle Hall, Clemson, SC 29634
This lecture introduces the concepts and governing principles behind the design, fabrication and application of biosensors to problems in environmental monitoring, biomedical diagnostics and industrial process monitoring. Emphasis is on the molecular design and rationale for the role of biologically-inspired polymers in resisting biofouling, non-specific interactions and promoting in vivo biocompatibility. Approaches for conferring biospecificity through the use of enzymes, antibodies and DNA will be introduced. Attention is also given to immobilization of molecular recognition moieties within such polymers and the immobilization of such polymers onto semiconductor, glass and metallic transducers.