Synthetic chemical contributions toward diagnostic and pharmaceutical products

ORGN 618

David A. Betebenner, david.betebenner@abbott.com, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064
Chemists engaged in research in diversified healthcare companies have an opportunity to contribute to the development of a range of medically beneficial products. In this presentation, examples of chemical contributions toward diagnostic and pharmaceutical products will be presented. The role of synthetic chemistry in the development of two diagnostic products, an immunoassay for quinidine and a hepatobiliary imaging agent, will be discussed. In the area of pharmaceutical research, medicinal chemistry contributions toward novel therapeutic agents for two medically important diseases will be presented. The first will pertain to the discovery of new structure-activity relationships that led to the discovery of a commercially successful HIV protease inhibitor. The second will discuss the synthesis of a potent anti-diabetes agent that is currently undergoing clinical trials.