Building biological layers on silicone elastomers using redistributive erosion/growth mechanisms

POLY 337

Michael A. Brook, mabrook@mcmaster.ca1, Lihua Liu1, Heather Sheardown, sheardow@mcmaster.ca2, Hong Chen, hongchen@mail.whut.edu.cn3, Yang Chen1, and Diana Morarescu, morared@univmail.cis.mcmaster.ca2. (1) Department of Chemistry, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4M1, Canada, (2) Department of Chemical Engineering, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L7, Canada, (3) Wuhan University of Technology, Institute of Materials Science and Engineering, 133 Luoshird, 430070 Wuhan
Reduction of the hydrophobicity of silicones is advantageous for their use as biomaterials. The equilibration of dimethylsilicone elastomers with triflic and methanol, a poor solvent, in the presence of (MeHSiO)n led to Si-H functional rough surfaces. Micron sized pillars of up to 100 nm in depth were formed depending on solvent conditions and time of exposure. These are likely due to erosion of the dimethylsilicone base, a process that competes with the surface incorporation of MeHSiO groups. The surfaces were modified with poly(ethylene oxide) terminated with NHS groups. Subsequent grafting with amine containing molecules, including peptides, proteins and carbohydrates, led to functional surfaces that demonstrated different selectivity for plasma protein adsorption.
 

Silicones and Silicone-Modified Materials
8:30 AM-12:00 PM, Tuesday, 12 September 2006 San Francisco Marriott -- Salon A2, Oral

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006