Further studies on the anticancer activity of citrus limonoids

AGFD 97

Edward G. Miller, emiller@bcd.tamhsc.edu1, Samuel E. Taylor, staylor@bcd.tamhsc.edu1, John M. Wright, jwright@bcd.tamhsc.edu2, Guddadarangavvanahally K. Jayaprakasha, gkjp@neo.tamu.edu3, and Bhimanagouda S. Patil, b-patil@tamu.edu4. (1) Biomedical Sciences, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, (2) Diagnostic Sciences, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, (3) Vegetable and Fruit Improvement, Department of Horticultural Sciences, Texas A&M University, 1500 Research Parkway, Ste A120, College Station, TX 77845, (4) Vegetable and Fruit Improvement Center, Texas A&M University, 1500 Research Parkway Suite A120, College Station, TX 77845
Earlier research has shown that some citrus limonoids can inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral tumors. In this study, three new limonoids [deacetyl nomilin (dan), limonin-7-oxime (lo), and obacunone 17-b-D-glucopyranoside (og)] were tested for activity. The hamster cheek pouch model was utilized and the solutions of the limonoids (2.5%-3.5%) and the solution of DMBA (0.5%) were applied topically to the pouches. Control animals were treated with the solvent used to dissolve the limonoids and the DMBA solution. Both dan and og significantly lowered (Student t-test) tumor number [6.64 (control group), 4.07 (dan group), and 3.53 (og group)], and og significantly lowered tumor burden [211 (control group) vs. 72.9 mm3 (og group)]. Lo was inactive. The results suggest that limonoids might be contributing to the cancer chemopreventive activity of citrus products. Supported by a grant from the USDA-CSREES-IFAFS 2001-52102-02294 through the Vegetable and Fruit Improvement Center.
 

General Posters
1:00 PM-3:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Agricultural & Food Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006