Synthesis of nitrilotriacetic acid-end-functionalized polystyrene using atom transfer radical polymerization

POLY 217

Hong Youl Cho, tnt1lbs@gmail.com1, Sung Bo Ko, oyes12@korea.com2, and Hyun-Jong Paik, hpaik@pusan.ac.kr1. (1) Department of Polymer Science and Engineering, Pusan National University, Busan, South Korea, (2) Daejeon Bio Venture Town, Cos Biotech, 461-58, Jeonmin-Dong, Yusong-Gu, Daejeon, 305-811, South Korea
Polymers with end-functional groups have been found in a wide range of applications. The use of functional initiators is one of the methods for preparing end-functionalized polymer. Among various radical polymerization methods, Atom Transfer Radical Polymerization (ATRP) has advantages of the use of functional initiators. Moreover, ATRP controls the polymers with predetermined molecular weight and narrow molecular distribution. In this study, we synthesized nitrilotriacetic acid (NTA) end-functionalized polystyrene using ATRP. As NTA complexed with Ni2+ is well-known to have strong interaction with a sequence of histidine residues (His tag), it is expected that the prepared NTA-end-functionalized polystyrene can be readily bioconjugated with various protein with His tag.
 

General Papers: Synthesis and Characterization
6:00 PM-8:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006