High molecular weight dendrimers for drug delivery applications

PMSE 166

Matthew C. Parrott, parrotmc@mcmaster.ca1, John Valliant, valliant@mcmaster.ca2, and Alex Adronov, adronov@mcmaster.ca1. (1) Department of Chemistry, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4M1, Canada, (2) Department of Chemistry, McMaster's University, 1280 Main St. West, Hamilton, ON L8S 4M1, Canada
We report the synthesis and characterization of a family of aliphatic polyester dendrimers functionalized with carborane cages in their interior. This family of dendrimers was prepared to high generation, exhibiting high molecular weight, high boron content, and excellent water solubility. These characteristics are ideal for boron neutron capture therapy (BNCT) an experimental cancer treatment. Presently, we are focused on introducing a 99mTc or Re atom within this family of dendrimers by incorporating an appropriate chelating ligand at the core of the dendrimer. The resulting dendrimers will be used as radio-active tracers for biodistribution studies.
 

Polymers for Biomedical Applications
8:30 AM-12:10 PM, Tuesday, 12 September 2006 San Francisco Marriott -- Salon B1, Oral

Division of Polymeric Materials: Science & Engineering

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006