Modeling conserved domains as units of protein structure and function

CHED 120

Elizabeth Hull, ehullx@midwestern.edu and William P. Baker. Biomedical Sciences Program, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308
Understanding the structure and function of proteins is an important part of the standards-based science curriculum. Experience indicates that within the topic of protein folding, the concept of protein domains proved particularly challenging for students. We have found that the concept of domains as modular units of structure and function within the tertiary structure of proteins can be effectively demonstrated using a hands-on investigative laboratory exercise and readily available resources. In this activity, students generate and test hypotheses about how proteins fold into domains and how these domains assemble into proteins. Complete methods and student guide are presented for using models of conserved protein domains, their role in the process of protein folding, and how abnormalities in protein folding can cause disease. The activity presented here is designed to actively engage students and promote both content mastery and critical thinking skills.
 

General Posters
7:30 PM-9:30 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Chemical Education

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006