Use of “click” chemistry to prepare functional cyclic polymers for transdermal drug delivery

PMSE 459

Scott Michael Grayson, sgrayson@tulane.edu, Boyd A. Laurent, blaurent@tulane.edu, and Dawanne M. Eugene, deugene@tulane.edu. Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, LA 70118
Linear polystyrene has been prepared by atom transfer radical polymerization such that the initiating group contains an alkyne and the terminal group an azide. The high efficiency of the “click” reaction enables the cyclization of the styrenic polymers. A slow addition technique has been used to enable nearly quantitative yield of the macrocycle, with little or no oligomerization byproduct. The inclusion of functional monomers is investigated toward the goal of preparing invertible cyclic micelles.
 

Polymers for Biomedical Applications
8:30 AM-12:00 PM, Wednesday, 13 September 2006 San Francisco Marriott -- Salon B1, Oral

Division of Polymeric Materials: Science & Engineering

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006