POLY 235 |
| Diacetylene-functional DTPA-TEG-PDA lipids and their biotin derivatives were prepared and used to prepare cross-linkable liposomes. Dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles have been made and they are small enough that they can be encapsulated into the DTPA-TEG-PDA liposomes. The resulting nanoparticle-containing liposomes can then be photo-crosslinked via their diacetylenic moieties. In the case that biotin groups are on the surfaces of liposomes, these nanoparticles can be linked to targeting moieties, such as oligopeptides containing Asn-Gly-Arg (NGR) sequences, by means of a biotin-avidin “bridge”. The targeting groups may thus direct the nanoparticles towards neovasculature by NGR-CD13 recognition. |
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7th International Biorelated Polymers Symposium
8:30 AM-12:40 PM, Monday, 11 September 2006 San Francisco Marriott -- Salon 14/15, Oral
Division of Polymer Chemistry |