Kinetic and thermodynamic behavior of recognition processes employing nano-spherical L-boc-phenylalanine anilide molecularly imprinted poly(MAA-co-EGDMA) monoliths

POLY 483

Saygun Sezgin1, Achim Weber, achim.weber@igb.fraunhofer.de2, Marc Herold, mhe@igb.fhg.de2, Carmen Gruber-Traub2, Herwig Brunner2, and Günter E. M. Tovar, guenter.tovar@igb.fraunhofer.de2. (1) Department of Biomimetic Surfaces, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Nobelstr. 12, Stuttgart, 70569, Germany, (2) Department of Biomimetic Surfaces, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Nobelstr. 12, Stuttgart, 70569, Germany
Molecular imprinting is a template polymerization which produces artificial binding sites in polymers. We synthesize highly crosslinked copolymer networks, e.g. poly(methacrylic acid-co-ethylene glycol dimethacrylate) nanoparticles by miniemulsion polymerization in presence of amino acids derivates as templates to generate sterically fixed sites for a specific recognition. We investigated and compared the kinetic and thermodynamic properties of the recognition process for the molecular template L-Boc-phenylalanineanilid and the influence parameters as the choice of environmental solvent or pretreatment of the synthesized nanoparticles. Therefor recognition experiments at the equlibrium were accomplished in different temperatures and solvents, quantified by HPLC and accounted with different adsorption models. By application of BET measurements, scanning electron microscopy and PCS selective information of morphology, surface area and the swelling properties of Nano-MIPS was achieved. Our assays show an extensive influence of polarity of the sovent medium in the binding step.
 

Nanoparticles and Microparticles: Synthesis and Applications
6:00 PM-8:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006