Bulk domains in biodegradable phosphoryl choline ionomers provides temporary reservoirs for the loading and release of proteins

PMSE 169

Fredrik Nederberg, fredrikn@us.ibm.com1, Björn Atthoff, atthoff@polymer.uu.se2, Tim Bowden2, Ken Welch, ken.welch@angstrom.uu.se3, Maria Stroemme, maria.stromme@angstrom.uu.se3, and Jöns Hilborn, joens.hilborn@polymer.uu.se2. (1) Department of Polymer Chemistry, Uppsala University, Box 538, Uppsala, 75121, Sweden, (2) Department of Materials Chemistry, Uppsala University, Lägerhyddsvägen 1, Uppsala, 751 21, Sweden, (3) Department of Engineering Sciences, Uppsala University, Box 534, Uppsala, 75121, Sweden
In this report the increased understanding of the water swelling properties and the subsequent formation of bulk water domains in biodegradable poly (trimethylene carbonate) (PTMC) phosphoryl choline (PC) ionomers is presented. The surface initiated water absorption in biodegradable PC ionomers, which forms a porous co-continuous structure, suggests that these materials are excellent candidates for drug delivery. Proteins could be loaded and released simply by soaking the material in water, thus providing new possibilities for full protein delivery.
 

Polymers for Biomedical Applications
8:30 AM-12:10 PM, Tuesday, 12 September 2006 San Francisco Marriott -- Salon B1, Oral

Division of Polymeric Materials: Science & Engineering

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006