Polymer hydrogel system "cell-container" by water-soluble phospholipid polymers for cell transplantation therapy

PMSE 462

Tomohiro Konno, konno@mpc.t.u-tokyo.ac.jp, Department of Materials Engineering, and Center for NanoBio Integration, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan and Kazuhiko Ishihara, ishihara@mpc.t.u-tokyo.ac.jp, Department of Materials Engineering, Bioengineering, and Center for NanoBio Integration, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
We have been reported that the 2-methacryloyloxyehtyl pshophorylcholine (MPC) polymers containing phosphatidylcholine group in the side chain have an excellent blood compatibility due to inhibit the nonspecific protein adsorption from biological media. It is important for not only cells but also proteins to have weak interaction with the hydrogel. It is well known that the boronic acid moiety is introduced in the polymer chain and the polymer is mixed with multivalent alcoholic compound, it is expected to make cross-linking reactions between these compounds. In this study, we designed a new MPC polymer containing p-phenylboronic acid moiety, that is, poly[MPC-co-n-BMA-co-p-vinylphenylboronic acid (VPBA)](PMBV). In this study, we report the synthesis and characterizations of new MPC polymer, formation and properties of hydrogel with polyol compound such as poly(vinyl alcohol), and behavior of fibroblast cells on/in the cell-container.
 

Polymers for Biomedical Applications
8:30 AM-12:00 PM, Wednesday, 13 September 2006 San Francisco Marriott -- Salon B1, Oral

Division of Polymeric Materials: Science & Engineering

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006