Intelligent drug release and biosurfaces by poly(methacrylic acid)-l-polyisobutylene amphiphilic polyelectrolyte conetworks

POLY 51

Márton Haraszti, Department of Polymer Chemistry and Material Science, Chemical research Center, Hungarian Academy of Sciences, Pusztaszeri u. 59-67, P. O. Box 17, H-1525 Budapest, Hungary, Béla Iván, bi@chemres.hu, Department of Polymer Chemistry and Material Science, Institute of Materials and Environmental Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri u. 59-67, P. O. Box 17, Budapest, H-1525, Hungary, and Kevin M. Shakesheff, School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom.
A series of novel amphiphilic polyelectrolyte conetwork, poly(methacrylic acid)-l-polyisobutylene (PMAA-l-PIB), was synthesized by a two-step copolymerization-deprotection process in a wide composition range. Under simulated conditions for the alimentary canal, intelligent drug release was performed with these conetworks as drug release matrices. Cell adhesion investigations showed that the biological response of PMAA-l-PIB surfaces is controlled by a structural factor of these new unique materials. As a consequence, biomaterial design is possible for targeted applications on the basis of these findings.
 

7th International Biorelated Polymers Symposium
1:30 PM-5:30 PM, Sunday, 10 September 2006 San Francisco Marriott -- Salon 14/15, Oral

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006