Attachment of amoxicillin to expanded polytetrafluoroethylene (ePTFE) microwave plasma modified surfaces

POLY 413

Nattharika Aumsuwan, marek.urban@usm.edu and Marek W. Urban, marek.urban@usm.edu. School of Polymers and High Performance Materials, The University of Southern Mississippi, Department of Polymer Science, 118 College Drive, PO 10076, Hattiesburg, MS 39406
Microwave plasma reactions in the presence of maleic anhydride have been developed to create acid functional groups on expanded polytetrafluoroethylene (ePTFE) surfaces which are capable of further reactions. Such surfaces were utilized for reactions with amoxicillin through ammonolysis reactions to create anti-microbial surfaces. These reactions also lead to surface morphological changes which were analyzed using scanning electron microscopy (SEM). Spectroscopic analysis using attenuated total reflectance fourier transform infrared spectroscopy (ATR FT-IR) and internal reflection IR imaging (IRIRI) allowed us to determine the formation of amide linkages resulting from reactions between amoxicillin and anhydride functionalities.
 

7th International Biorelated Polymers Symposium
6:00 PM-8:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006