Synthesis of hydrophobic-water soluble N-acyl chitosan derivatives

POLY 167

Lakia M. Champagne, lchamp2@lsu.edu, Chemistry, Louisiana State University, 744 Choppin Hall, Baton Rouge, LA 70803-1804 and William H. Daly, chdaly@lsu.edu, Department of Chemistry, Louisiana State University, 712 Choppin Hall, Baton Rouge, LA 70803-1804.
Currently, natural polysaccharides are being utilized increasingly in the markets because they exhibit versatility, biodegradability, biocompatibility, and are found abundantly in nature. Chitosan is a polysaccharide that displays excellent versatility and is recognized for its modest bactericidal properties, towards the bacterium Escherichia coli and Staphylococcus Aureus. Innovative procedures to modify chitosan are proposed to optimize the polymer's bactericidal properties. Optimization is achieved by substituting the backbone of chitosan with distinctive anhydrides and lactones, and subsequent quaternization using N-3-chloro-2-hydroxyl propyl trimethyl ammonium chloride (Quat-188). The resultant polymers are water-soluble over an entire range of pH's and exhibit enhanced bactericidal properties.
 

General Papers: Synthesis and Characterization
6:00 PM-8:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006