Manufacturing monodisperse gelatin microparticles using a microfluidic chip

POLY 486

Keng-Shiang Huang, huangks@mail.ncku.edu.tw, Engineering Science, National Cheng Kung University, Tainan, Taiwan, Jia-Yaw Chang, JYChang@itri.org.tw, Nanopowder & thin film technology center, Industrial Technology Research Institute, Tainan, Taiwan, and Chih-Hui Yang, Department of Biological Science & Technology, I-Shou University, Kaohsiung, Taiwan.
The purpose of this study was to prepare monodisperse gelatin microparticles using a microfluidic chip. We have demonstrated that one can control the size of gelatin microparticles from 100 µm to 1000 µm in diameter (with a variation less than 10 %) by altering the relative sheath/sample flow rate ratio. Our strategy is based on a focusing on the forming a uniform self-assembling sphere structure, so-called water-in-oil (w/o) emulsions, in the cross-junction microchannel. These fine emulsions, consisting of aqueous 3 % (wt/wt) gelatin and 1 % (w/v) genipine, are then undergoing cross-linking reaction to accomplish water-insoluble gelatin microparticles in an efficient manner.
 

Nanoparticles and Microparticles: Synthesis and Applications
6:00 PM-8:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006