Biohybrid block copolymer architectures by "click" chemistry

POLY 553

Joost A. Opsteen, j.opsteen@science.ru.nl1, A. J. Dirks, a.dirks@science.ru.nl2, Sander S. van Berkel, s.vanberkel@science.ru.nl1, Nikos S. Hatzakis, N.Hatzakis@science.ru.nl1, Rene P. Brinkhuis, r.p.brinkhuis@student.science.ru.nl1, Marieke E. G. Reijnders, meg.reijnders@student.science.ru.nl1, and Jan C. M. van Hest, j.vanhest@science.ru.nl1. (1) Department of Organic Chemistry, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands, (2) Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, Nijmegen, 6525 ED, Netherlands
Merging properties of biomolecules, such as programmed assembly, recognition and bioactivity, with the versatility and tailorability of synthetic polymers leads to a new class of hybrid macromolecules which have much potential in medicine, nanotechnology and biotechnology. However, the presence of many functional groups in biopolymers makes it difficult to conjugate them with synthetic polymers in a controlled fashion. Due to its efficiency and specificity, the "click" reaction between azides and acetylenes is a powerful tool in bioconjugation. We have exploited this type of "click" chemistry to synthesize (biohybrid) block copolymers and to functionalize polymersomes.
 

7th International Biorelated Polymers Symposium
8:30 AM-12:40 PM, Wednesday, 13 September 2006 San Francisco Marriott -- Salon 14/15, Oral

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006