POLY 278 |
| We have prepared two types of biomolecule-responsive hydrogels (biomolecule-cross-linked hydrogel and biomolecule-imprinted hydrogel) by using biomolecular complexes as reversible cross-linking points. This paper describes two biomolecule-responsive hydrogels that undergo volume changes in response to target biomolecules such as tumor marker glycoprotein and single-stranded (ss)DNA, which were prepared by using biomolecular complexes such as antigen-antibody complexes, saccharide-lectin complexes and DNA duplexes. DNA-responsive hydrogels as biomolecule-cross-linked hydrogels and tumor marker-responsive hydrogels as biomolecule-imprinted hydrogels were prepared by bioconjugation of PAAm networks with DNAs, lectins and antibodies. DNA-cross-linked hydrogels recognized the sequence of ssDNA and swelled gradually in response to the sequence of ssDNA. Tumor marker-imprinted hydrogels only shrank when both lectin and antibody in the hydrogels simultaneously recognized the saccharide and peptide chains of the target glycoprotein. |
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7th International Biorelated Polymers Symposium
1:30 PM-5:10 PM, Monday, 11 September 2006 San Francisco Marriott -- Salon 14/15, Oral
Division of Polymer Chemistry |