POLY 613 |
| Amphiphilic PEG-terminated hyperbranched poly(amino ester)s were obtained by the reaction of the vinyl terminal groups of hyperbranched poly(amino ester)s precursors with amine-capped PEG. The strucutre of the polymers were characterized using 1H and 13C NMR. Self-assembly of the amphiphilic PEG-terminated hyperbranched poly(amino ester)s in aqueous solution were investigated using TEM, DLS and NMR. The results showed that nanosized micelles were formed with the hyperbrached poly(amino ester)s as the core and the PEG as the shell. The micelles were stable in aqueous solution over ten days probably due to the slow hydrolytic rate of the hyperbranched poly(amino ester)s core. PEG length has little effects on the stability of the micelles and CMC of the polymers in aqueous solution. Nile Red can be encapsulated in the micelles and the release rate at pH 7 was slow. The effect of pH on the release profiles and the applications of this system for drug delivery are being investigated. |
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7th International Biorelated Polymers Symposium
1:30 PM-5:20 PM, Wednesday, 13 September 2006 San Francisco Marriott -- Salon 14/15, Oral
Division of Polymer Chemistry |