Preparation of freestanding nano-adhesive plasters having hetero-surfaces

POLY 234

Shinji Takeoka, takeoka@waseda.jp, Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University, 3-4-1, Ohkubo, Shinjuku, Tokyo, 169-8555, Japan and Yosuke Okamura, y.okamura@ruri.waseda.jp, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1, Ohkubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
Nano-adhesive plaster is a biodegradable polymeric sheet with nanometer thick; the one side is adhesive to a wound and the other side has blood compatibility. We used three kinds of polymeric sheets; one type is a sheet made by cross-linking of human serum albumin (HSA) absorbed on a patterned octadecyltrimethoxysilane monolayer, second is a sheet made by a layer-by-layer technology with anionic and cationic polysaccharides, and third is a sheet made by thermal fusion of polymeric particles. These sheets on the plate were detached from the surface in the treatment with some surfactants and sacrificial layers to prepare the dispersion of a nano adhesive plaster. Furthermore, we can modify the surface of the sheet on the plate with blood compatible polymers such as adhesive proteins or ligands after detachment to provide hetero surface. We will also report adhesive behavior of the sheets interacting with vascular injury under flow conditions.
 

7th International Biorelated Polymers Symposium
8:30 AM-12:40 PM, Monday, 11 September 2006 San Francisco Marriott -- Salon 14/15, Oral

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006