Complexities of the registration process for the six main agricultural fumigants with particular reference to metam sodium and MITC

AGRO 13

Ian S. Chart, ianc@amvac-chemical.com, Regulatory Affairs Department, Amvac Chemical Corporation, 4695 MacArthur Court, Suite 1250, Newport Beach, CA 92660
The registration/re-registration of the six main agricultural fumigants (methyl bromide, 1,3-dichloropropene, iodomethane, metam sodium, dazomet and chloropicrin) present several new and unusual problems for the US regulatory authorities. The fumigants are all at different stages of the regulatory cycle but their use patterns are interrelated. One of the main areas of concern is bystander exposure for which there are at least three potential modeling systems, all of which have been approved for use by the SAP. To add to the complexity, at least two of the compounds have human studies associated with the regulatory endpoint. These studies have still to be reviewed by the Human Studies Review Board (HSRB). The presentation will cover the latest position on this complex process with particular reference to metam sodium and MITC.