Fumonisins are known to be potent toxin mold from Fusarium Moniliforme in some grains, which causes equine leukoencephalomalacia, procine pulmonary edema, and esophageal cancers from some countries, and they are known to be ceramide synthase inhibitors.  The syntheses of fumonisins B₁ and B₂ will be introduced.  Retrosynthetic strategy of the fumonisins was started from C₁-C₁₀ section of aldehyde and C₁₁-C₂₀ section of alkyl iodide, respectively.  For C₁-C₁₀ section, diastereoselectively reductive alkylation with Schiff-base amino acid derivatives and a mixture of iBu₂AlH and iBu₃Al has been utilized for core methodology, and chiral auxiliary-based alkylation and stereoselective dihydroxylation have produced the alkyl iodode for C₁₁-C₂₀ section.  Fumonisin analogues will also be suggested, which may have different number and stereochemistry of hydroxyl groups, and form different carbon chains.