POLY 78 |
| The controlled and stable immobilization of one or multiple types of (bio)molecules to a surface has been identified as one of the critical challenge in the areas of biochips and biosensors. Using chemical vapor deposition co-polymerization, we have developed a simple strategy towards multi-functional surfaces presenting two different biological ligands in controllable ratios. For CVD co-polymerization, mixtures of 4-trifluoroacetyl [2.2]paracyclophane and 4-aminomethyl [2.2]paracyclophane were sublimated, converted to the corresponding quinodimethanes (monomers) and co-polymerized onto the substrate. CVD co-polymerization of 1 and 2 resulted in transparent and topologically uniform polymer films with functional groups in controllable ratios. All polymer films are characterized by X-ray photoelectron spectroscopy, infrared spectroscopy, X-Ray diffraction analysis, imaging ellipsometry and fluorescence imaging (after binding). These modularly designable polymer coatings are applicable to a wide range of biomedical devices including microanalytical or diagnostic systems. |
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Polymers in Biosensors and Biochips
1:30 PM-4:40 PM, Sunday, 10 September 2006 San Francisco Marriott -- Salon 12/13, Oral
Division of Polymer Chemistry |