ANYL 249 |
| Hollow polyelectrolyte capsules prepared via the layer-by-layer method have potential application in drug delivery, diagnostics, and sensing. One of the key features of the capsules is the ability to control the diffusion of molecules through the capsule wall, whether it be to trap the molecule inside the capsule, or to allow diffusion in or out of the capsule. We will outline a new method based on DNA Molecular Beacon technology that allows high throughput analysis of the diffusion of DNA into the capsules. Most importantly, this technique uses low concentrations of DNA that does not need to be modified in any way. We show that this technique can be used to determine the diffusion of DNA though various polyelectrolyte multilayer films. We will also outline methods to detect femtogram quantities of material deposited onto the capsules. These techniques will aid the development of new, nanostructured films with controlled permeability. |
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Analytical Approaches: Sensors
8:30 AM-11:40 AM, Wednesday, 13 September 2006 Moscone Center -- Room 123, Oral
Division of Analytical Chemistry |