ANYL 123 |
| Improved methods for selective detection of highly toxic organophosphorus compounds are needed. In an effort to develop sensors that distinguish between various organophosphorus compounds based on their toxicity, we have developed a series of fluorophores based on dipyrido-[3,2-a:2'3'-c]phenazine (DPPZ). The synthesis and interaction of 3,6-dimethylbenzo[i]dipyrido-[3,2-a:2'3'-c]phenazine (DM-BDPPZ), with various organophosphorous compounds was studied. In acetonitrile, DM-BDPPZ fluoresces green. Addition of the nerve gas analogue diethylchlorophosphate (DCP) resulted in fluorescence color change from green to orange accompanied by an increase in fluorescence intensity and lifetime. However, addition of the nerve gas analogue dimethyl methylphosphonate (DMMP) resulted in a slight increase in fluorescence intensity and lifetime, but no color change. Fluorescence intensity of DM-BDPPZ upon addition of fenthion, an organophosphorus pesticide, resulted in fluorescence quenching and the lifetime decreased. The ability of DPPZ derivatives to distinguish between various organophophorus compounds, is a unique feature and a significant requirement for building novel organophosphorus sensors. |
|
General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Analytical Chemistry |