ANYL 80 |
| The demand for new antimicrobials and improving the efficacy of current antibiotics results in alternative therapeutic approaches. Combating the bacterial resistance toward conventional β-lactam antibiotics requires novel mechanisms of action. N-thiomethylated monocyclic β-lactams are shown to be effective against multidrug resistant microbial strains. In this study we are exploring the potential of C-thiomethylated β-lactams. Selected C-methylthiolated monocyclic β-lactams are examined for their potential to chelate mono-, di- and tri-valent cations. Different metal salts are used and the ability of the β-lactams to form metal adducts are investigated by ESI-MS. |
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General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Analytical Chemistry |