MEDIWednesday, 29 March 2006

8:30 AM-12:05 PM Georgia World Congress Center -- Georgia Ballroom 1, Oral
Geldanamycin and Beyond: Progress Toward the Development of HSP90 Inhibitors
Organizers:Brian S. J. Blagg
Robert A. Galemmo Jr.
8:30 AMIntroductory Remarks
8:35 AMIs heat shock protein 90 the cancer chaperone?
Len Neckers
9:10 AMDesign and development of purine-scaffold inhibitors of the heat shock protein 90
Gabriela Chiosis
9:45 AMRationally designed high-affinity 2-amino-6-halopurine Hsp90 inhibitors which exhibit potent antitumor activity
Srinivas R. Kasibhatla, Kevin Hong, Marco A. Biamonte, David Bush, Patricia L. Karjian, John L Sensintaffar, Adeela Kamal, Rachel E. Lough, John Brekken, Karen Lundgren, Roy Grecko, Gregg A. Timony, Yingqing Ran, Robert Mansfield, Lawrence C. Fritz, Ed Ulm, Francis J. Burrows, Marcus F. Boehm
10:20 AMManaging the Hsp90-mediated protein folding process with small molecules
Brian S. J. Blagg
10:55 AMSemisynthetic analogs of geldanamycin: Chemistry and biology
David C. Myles
11:30 AMSynthesis and biological evaluation of IPI-504, an aqueous soluble analog of 17-AAG and potent inhibitor of Hsp90
James R. Porter, Jie Ge, Emmanuel Normant, Janid Ali, Marlene S. Dembski, Yun Gao, Asimina T. Georges, Louis Grenier, Roger Pak, Jon Patterson, Jens R. Sydor, Jim Wright, Julian Adams, Jeffrey K. Tong

Symposium Grid -- Division of Medicinal Chemistry -- Session Listing

Symposium Grid -- Drug Discovery -- Session Listing

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006